Cough syrup need to consequently not be used right until two weeks once the finish of therapy with MAO inhibitors. With simultaneous consumption of analgesics (e.B. acetylsalicylic acid or paracetamol) the analgesic impact of those substances may well mutually improve.

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La codeina è un analgesico (allevia il dolore) dotato anche di effetto contro la tosse. Agisce modificando il modo in cui il cervello e il sistema nervoso rispondono al dolore e riducendo l'attività delle aree cerebrali che controllano la tosse.

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fentanyl transdermal and codeine each increase sedation. Stay clear of or Use Alternate Drug. Limit use to patients for whom different cure alternatives are insufficient

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Codeine is contraindicated in patients that are recognized to be ultrafast CYP2D6 metabolisers: Codeine is converted in more info its Lively metabolite morphine through the hepatic isoenzymes CYP2D6, a number of which exist with genetic polymorphisms.

Patients with the “ultrafast CYP2D6 metabolizer” phenotype Have click here a very substantial CYP2D6 action, so poisonous serum levels of morphine can take place even at lower doses.